PROPOSAL:
QLK1-1999-00179
ACRONYM
EUROFEDA
AREA:
FP5 - QoL, 5/ 1:Food, Nutrition and Health 3 - Research into the role of food in promoting and sustaining health with respect to diet and nutrition ….
Call number / date:
1a
PROJECT TYPE:
Coordination Research Actions
EU CONTRIBUTION:
574,076
STARTING DATE:
1999-12-31
DURATION:
36 months
Coordinator: Dr. S. Astley, Institute of Food Research Norwich, Nutrition and Consumer Science, Norwich Research Park, UK -NR4 7UA, Norwich, United Kingdom, Email: sian.astley@bbsrc.ac.uk
Project Description:
Epidemiological evidence supporting the link between higher intakes of foods containing compounds with antioxidant properties (e.g. vitamins E and C, and the carotenoids) and reduced risk of human chronic diseases is substantial. The precise relationship between the chemical composition of food and our health, however, remains elusive.
There is substantial evidence supporting the fact that certain phytochemicals are able to stimulate cellular antioxidant responses in reply to oxidative stress. Intervention studies using isolated antioxidant compounds (natural and synthetic, individually or combined doses) have not shown any consistent trend indicating they confer human health although studies using whole foods have. EUROFEDA has produced an up-to-date review of the known effects of dietary antioxidants at the molecular, cellular, tissue and whole body levels. This review will be published in January 2002 in Molecular Aspects of Medicine.
The review concentrates on three major areas in antioxidant research: Biomarkers of oxidant/ antioxidant activity in proteins, lipids and DNA, bioavailability and bioactivity in terms of oxidant/ antioxidant effects on gene expression and mitochondrial function. Particular emphasis has been placed on whether, or not, the effects observed are meaningful for human health and disease, in terms of the experimental systems used, the doses used (nutritionally relevant levels, duration and source), and whether the compounds or their metabolites are likely to reach target tissues in an active form.
Project URL: http://www.ifrn.bbsrc.ac.uk/EUROFEDA
Consortium:
Dr David Lindsay - participant 1
Euro Science Perspectives Ltd., 3, Patcham Grange, Brighton BN1 8UR
Dr Liam Breslin - participant 5
DG Research DG (Research) SQME, European Commission,
Rue de la Loi 200, B-1049 Brussels, Belgium
Dr Helen Griffiths - participant 29
Pharmaceutical Sciences, Aston University, Aston Triangle,
Birmingham B4 7ET
Professor Lennart Møller - participant 6
Karolinska Institute, CNT Novum,
Huddinge, S-14157 Stockhom, Sweden
Dr Wilhelm Stahl - participant 2
Institut für Physiologische Chemie I,
P.O. Box 10 10 07,
D-40001, Düsseldorf, Germany
Dr Trinette van Vliet- participant 7
TNO Nutrition & Food Research Institute,
P.O. Box 360, Utrechtseweg 48,
NL-3700 AJ Zeist, The Netherlands
Professor Malcolm Jackson - participant 3
Department of Medicine, Univeristy of Liverpool, L69 3GA
Professor Sergio Papa - participant 8
Institute of Medical Biochemistry & Chemistry,
Piazza G. Cesare, 70124, Bari, Italy
Professor Doctor Aalt Bast - participant 9
Univeristy of Maastricht, Faculty of Medicine,
Department of Pharmcology & Toxicology, P.O. Box 616,
NL-6200 MD Maastricht, The Netherlands
Professor Doctor Steffen Loft - participant 16
Institute of Public Health, Univerisity of Copenhagen,
C/o Department of Pharmacology, Panum Blegdamsvej 3,
DK-2200 N, Denmark
Dr Nora O'Brien - participant 18
Nutritional Sciences,
Department of Food Science & Technology,
Coláiste na hOllscoile Corcaigh, Cork, Eire
Dr Ryszard Olinski - participant 11
The L. Rydygier Medical University,
Department of Clinical Biochemistry,
ul. Karlowicza 24, PO-85-092 Bydgoszcz, Poland
Dr Andrew Collins - participant 12
Rowett Research Institute,
Greenburn Road, Bucksburn, Aberdeen
AB21 9SB Scotland
Dr Rachel Drake - participant 19
Trait Research, Syngenta,
Jealott's Hill International Research Centre,
Bracknell, Berkshire RG42 6ET
Dr Christine Gärtner - - participant 14
Cognis Deutschland GmbH,
P.O. Box 13 01 64, D-40551 Düsseldorf, Germany
Professor Catherine Rice-Evans - participant 10
Wolfson Centre for Age-Related Diseases,
Antioxidant Research Group,
Guy's, King's and St Thomas's School of Biomedical Sciences,
Hodgkin Building - 3rd Floor,
King's College London,
St Thomas's Street, London SE1 9RT
Dr Hans-Ulrich ter Meer, - participant 21
Director Food Technology,
Nutrinova, Nutrition Specialities & Food Ingredients GmbH,
Industriepark Hoechst D-706,
D-65926 Frankfurt, Germany
Doctor Carlo Bertoni-Freddari - participant 24
Dipartimento Richerche Gerontologiche,
I.N.R.C.A., Via Birarelli, 8, 60121 Ancona, Italy
Professor James Parry - participant 15
Centre for Molecular Genetics & Toxicology,
School of Biological Sciences, Prifysgol Cymru,
Abertawe (Swansea), Wales
Dr Simon Heales - participant 25
University College London, Department of Clinical Biochemistry,
National Hospital, Queen Square, London WC1N 3BG
Professor Doctor Peter Hollman - participant 31
RIKILT-DLO, P.O. Box 230, Bornsesteeg 45,
6700 AE Wageningen, The Netherlands
Dr Sophie Holm - participant 20
Centre du Recherche Pernod-Ricard, Ave du Maréchal Foch 120,
Creteil, Cedex 94015, France
Professor Frank Kelly - participant 30
King's College London, Centre for Cardiovascular Biology & Medicine,
Rayne Institute, St Thomas's Hospital, London SE1 7EH
Professor Pat Morrissey - participant 13
Nutritional Sciences,
Department of Food Science & Technology,
Coláiste na hOllscoile Corcaigh, Cork, Eire
Professor Sue Southon - participant 17
Organic Micronutrients, Diet, Health and Consumer Science,
Institute of Food Research, Norwich Research Park, Colney,
Norwich NR4 7UA
Dr Juan Bolaños - participant 26
Depto. de Bioquimica y Biologia Molecular,
Universidad Salamanca, Campus Miguel Unamuno,
37007 Salamanca, Spain
Dr Jan Øivind Moskaug - participant 23
Institute for Nutrition Research, P.O. Box 1046,
Blindern, N-0316 Oslo, Norway
Professor Doctor Klaus Schulze-Osthoff - participant 22
Division of Immunology & Cell Biology
University of Münster, Rontgenstrasse 21,
D-48149 Münster, Germany
Professor José Viña-Ribes - participant 27
Depto de Fisologia/ Facultad de Medicina
Universidad de Valencia, Avda Blasco Ibañez 17
46010 Valencia, Spain
Dr Lisa Jackson - participant 28
Foods Standards Agency, Nutrition Division,
R 310 Ergon House, 17, Smith Square, London SW1P 3JR
Dr Lilian Tijburg - participant 4
Unilever Research Vlaardingen,
Biosciences, Nutrition & Safety,
PO Box 114, NL-3130 AC Vlaardingen
The Netherlands
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